Protein tyrosine phosphatases in T-cell development, apoptosis and signalling

The study of phosphatases was viewed as a rather esoteric subject for immunologists until eight years ago, when the discovery that CD45 is a protein tyrosine phosphatase (PTPase) began to make the topic respectable. Now, as reviewed by Julie Frearson and Denis Alexander, PTPases are increasingly being shown to play key roles in the molecular physiology of haematopoietic cells and some have been shown to regulate critical events in T-cell development and signalling.