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Programmed cell death and cell transformation in craniofacial development

C F Shuler1

  • 1University of Southern California, School of Dentistry, Center for Craniofacial Molecular Biology, Los Angeles 90033, USA.

Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists
|January 1, 1995
PubMed
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It is time to move on.....

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Craniofacial development involves branchial arch fusion, where ectodermal epithelia initially adhere but must be removed. Programmed cell death, epithelial-mesenchymal transformation, or migration are key mechanisms for this removal during palate fusion.

Area of Science:

  • Developmental biology
  • Craniofacial development
  • Epithelial biology

Background:

  • Branchial arch fusion is critical for forming craniofacial structures like the mandible, lips, and palate.
  • Ectodermal epithelia play a role in initial tissue adherence during fusion.
  • The medial edge epithelium of palatal shelves must be removed for successful palate fusion.

Purpose of the Study:

  • To review the mechanisms responsible for epithelial cell removal from fusion zones during craniofacial development.
  • To discuss programmed cell death, epithelial-mesenchymal transformation, and epithelial migration as potential removal mechanisms.
  • To examine these mechanisms in the context of palatal fusion and other model systems.

Main Methods:

  • Literature review of developmental biology studies.

Related Experiment Videos

  • Analysis of morphologic and molecular events in branchial arch fusion.
  • Comparison of findings across different model systems for epithelial cell removal.

    • Main Results:

    • Epithelial cells initially mediate adherence between fusing branchial arch processes.
    • These cells are absent from the final fusion zone, necessitating their removal.
    • Programmed cell death, epithelial-mesenchymal transformation, and migration are hypothesized fates for these cells.

    Conclusions:

    • The disappearance of medial edge epithelium is essential for secondary palate fusion.
    • Multiple cellular mechanisms likely contribute to epithelial removal during craniofacial development.
    • Understanding these processes is key to comprehending craniofacial morphogenesis.