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Systemic retinoids for psoriasis

J M Wieder1, N J Lowe

  • 1Skin Research Foundation, Santa Monica, CA 90404, USA.

Dermatologic Clinics
|October 1, 1995
PubMed
Summary
This summary is machine-generated.

Systemic retinoids offer treatment options for various psoriasis types, including generalized pustular, exfoliative, and plaque psoriasis. This review covers their use in monotherapy and combination therapy, detailing dosing, side effects, and monitoring.

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Area of Science:

  • Dermatology
  • Pharmacology

Background:

  • Psoriasis is a chronic inflammatory skin condition with various subtypes.
  • Systemic retinoids represent a class of drugs with immunomodulatory and antiproliferative effects.

Purpose of the Study:

  • To review the efficacy and safety of systemic retinoids in treating different forms of psoriasis.
  • To provide guidance on dosing, side effect management, and monitoring for systemic retinoid therapy.

Main Methods:

  • Literature review of studies investigating systemic retinoids for psoriasis.
  • Analysis of data on monotherapy and combination therapy approaches.
  • Compilation of information on dosing, adverse events, and patient monitoring.

Main Results:

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  • Systemic retinoids are effective in managing generalized pustular psoriasis, exfoliative psoriasis, and plaque psoriasis.
  • Both monotherapy and combination therapy regimens show therapeutic benefits.
  • Established guidelines exist for dosing, managing side effects, and monitoring patients.

    • Conclusions:

    • Systemic retinoids are valuable therapeutic agents for specific psoriasis subtypes.
    • Careful patient selection and monitoring are essential for safe and effective treatment.
    • Further research may refine optimal treatment strategies using systemic retinoids.