Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Anti-estrogens and bone tissue]

C Ribot1, F Trémollières

  • 1Service d'Endocrinologie, CHU Purpan, Toulouse.

Annales D'Endocrinologie
|January 1, 1995
PubMed
Summary

Anti-oestrogens, like tamoxifen, show promise in preventing bone loss and lowering cholesterol in postmenopausal women. Further research may expand their use for managing estrogen deficiency.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Management of women with abnormal uterine bleeding: Clinical practice guidelines of the French National College of Gynaecologists and Obstetricians (CNGOF).

European journal of obstetrics, gynecology, and reproductive biology·2023
Same author

[Women with a very high risk of breast cancer: Contraceptives, hormonal replacement therapy use and personalized screening].

Gynecologie, obstetrique, fertilite & senologie·2023
Same author

Quality of life of patients with bilateral oophorectomy before the age of 45 for the treatment of endometriosis.

Maturitas·2022
Same author

[Management of women with abnormal uterine bleeding: Clinical practice guidelines of the French National College of Gynecologists and Obstetricians (CNGOF)].

Gynecologie, obstetrique, fertilite & senologie·2022
Same author

[Postmenopausal women management: CNGOF and GEMVi clinical practice guidelines (Short version)].

Gynecologie, obstetrique, fertilite & senologie·2021
Same author

[Menopause hormone treatment in practice. Postmenopausal women management: CNGOF and GEMVi clinical practice guidelines].

Gynecologie, obstetrique, fertilite & senologie·2021

Area of Science:

  • Pharmacology
  • Endocrinology
  • Oncology

Context:

  • Anti-oestrogens are non-steroidal compounds interacting with oestrogen receptors.
  • They exhibit tissue-specific agonist or antagonist effects.
  • Widely used in breast cancer treatment, their impact on bone and lipid metabolism is increasingly recognized.

Purpose:

  • To review the effects of anti-oestrogens on bone and lipid metabolism.
  • To evaluate their potential in preventing post-menopause oestrogen deficiency effects.
  • To explore new therapeutic applications beyond breast cancer.

Summary:

  • Tamoxifen, a key anti-oestrogen, demonstrates preventive effects against bone loss in animal models and postmenopausal women.
  • Clinical studies indicate tamoxifen's neutral to protective impact on bone density and its cholesterol-lowering properties.
  • Third-generation anti-oestrogens, such as raloxifene, are under investigation for enhanced bone and lipid benefits with limited endometrial effects.

Impact:

  • Findings support the development of novel anti-oestrogens for managing menopausal symptoms and bone health.
  • This research could broaden the use of anti-oestrogens in patients with contraindications for hormone replacement therapy.
  • Potential for improved quality of life for postmenopausal women through targeted therapies.

Related Experiment Videos