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Ectopic induction of cartilage and bone by bovine bone morphogenetic protein using a biodegradable polymeric
Y Yamazaki1, S Oida, K Ishihara
1Department of Plastic and Reconstructive Surgery, Kitasato University, Japan.
Journal of Biomedical Materials Research
|January 1, 1996
Abstract:
Two kinds of bone morphogenetic protein (BMP) containing polymeric reservoirs made from poly(lactide-co-glycolide) (PLG) and a mixture of PLG/poly(ethylene glycol) (PEG) (PLG/PEG) were implanted into mice femoral muscles. In the PLG/PEG reservoir with BMP, bone formation was induced within 3 weeks. On the other hand, in the PLG reservoir with BMP scarcely any bone formation could be observed. The results suggest that the carrier system is most important for the development of BMP-induced bone formation and the PLG/PEG reservoir system is available for BMP delivery.