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Substrate metabolism in humans: 1995 A.S.P.E.N. research workshop
1Department of Internal Medicine, Washington University School of Medicine, St Louis, Missouri 63110-1093, USA.
JPEN. Journal of Parenteral and Enteral Nutrition
|January 1, 1996
Summary
Investigating human substrate metabolism using in vivo studies provides crucial data for understanding health and disease. This approach is vital for effective nutritional and metabolic patient management.
Area of Science:
- Human metabolism
- Nutritional science
- Physiology
Background:
- The 1995 A.S.P.E.N. Research Workshop convened experts to discuss human substrate metabolism.
- Focus was on the regulation of energy, carbohydrate, lipid, and protein metabolism in health and disease.
Framework:
- Utilized state-of-the-art presentations and in vivo human studies.
- Incorporated both published and unpublished data from leading researchers.
Implementation:
- Employed advanced methodologies including nuclear magnetic resonance spectroscopy, compartmental modeling, and stable isotope tracers.
- Techniques like microdialysis and abdominal vein catheterization were used.
Implications:
- In vivo investigation is the optimal method for generating physiologically relevant human data.
- Understanding human intermediary metabolism is essential for clinical nutrition and disease management.