Transcriptional regulation of the 5-HT2A receptor

Complex transcriptional control mechanisms are responsible for the cell-type and antidepressant-induced regulation of the 5-HT2A receptor. Repressor domains in the 5' flanking region of the 5-HT2A receptor gene are the primary determinants to generate neuronal cell-specific transcription. Glial cell expression of the 5-HT2A receptor is achieved through a cell-type specific promoter activation. The downregulation of the 5-HT2A receptor by the atypical antidepressant mianserin is mediated by a drug response sequence in the 5' flanking region of the receptor gene.