Potential mechanisms of interferon neurotoxicity

This article examines potential mechanisms underlying the neurologic toxicities associated with interferon therapy in patients with cancer. The following mechanisms for interferon-related toxicities have been proposed: changes in certain neuroendocrine hormone levels; structural similarities and common pathways between interferon and specific neuroendocrine hormones; and the immunoregulatory effects of interferon. Strategies for the assessment and management of interferon-related neurologic toxicities are discussed. A reduction in dose or discontinuation of interferon may be recommended if interferon neurotoxicity develops. Additional interventions may include reorientation strategies, provision of uninterrupted periods of rest, and safety precautions. Directions for future research are recommended.