Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Blunt brain injury activates the coagulation process

F Hulka1, R J Mullins, E H Frank

  • 1Department of Surgery, Oregon Health Sciences University, Portland, USA.

Archives of Surgery (Chicago, Ill. : 1960)
|September 1, 1996
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Ketone Ester Effects on Biomarkers of Brain Metabolism and Cognitive Performance in Cognitively Intact Adults ≥ 55 Years Old. A Study Protocol for a Double-Blinded Randomized Controlled Clinical Trial.

The journal of prevention of Alzheimer's disease·2022
Same author

Physical inactivity and knee osteoarthritis in guinea pigs.

Osteoarthritis and cartilage·2019
Same author

Sustained intra-cartilage delivery of low dose dexamethasone using a cationic carrier for treatment of post traumatic osteoarthritis.

European cells & materials·2017
Same author

Cold urticaria: a 20-year follow-up study.

Journal of the European Academy of Dermatology and Venereology : JEADV·2016
Same author

Increases in anaphylaxis fatalities in Australia from 1997 to 2013.

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology·2016
Same author

Moderate dynamic compression inhibits pro-catabolic response of cartilage to mechanical injury, tumor necrosis factor-α and interleukin-6, but accentuates degradation above a strain threshold.

Osteoarthritis and cartilage·2013

Coagulopathy is common after blunt brain injury, increasing death risk. Early intervention for this consumptive coagulopathy syndrome is crucial for effective treatment.

Area of Science:

  • Trauma Surgery
  • Hematology
  • Neurology

Background:

  • Blunt brain injury can lead to coagulopathy, a complex bleeding disorder.
  • Understanding the prevalence and characteristics of coagulopathy is vital for patient outcomes.

Purpose of the Study:

  • To determine the frequency of coagulopathy in patients with blunt brain injury.
  • To characterize the coagulopathy syndrome and its association with injury severity and mortality.

Main Methods:

  • Retrospective study of 159 patients with blunt head trauma admitted to a Level I trauma center.
  • Coagulopathy assessed using a disseminated intravascular coagulation score based on platelet count, prothrombin time, partial thromboplastin time, fibrinogen, and D-dimer levels.
  • Intracranial injury confirmed by computed tomography (CT) of the brain.

Related Experiment Videos

Main Results:

  • 41% of patients with brain injury exhibited coagulopathy (disseminated intravascular coagulation score ≥ 5), compared to 25% without brain injury.
  • Patients with brain injury and coagulopathy had a higher mortality rate (P < .05) and more frequent deterioration on CT scans.
  • Profound fibrinogen depletion occurred within 4 hours of injury in brain-injured patients.

Conclusions:

  • Disseminated intravascular coagulation syndrome can cause consumptive coagulopathy after blunt brain injury, significantly increasing mortality risk.
  • This syndrome develops rapidly, within 1 to 4 hours post-injury.
  • Prompt therapeutic interventions are necessary for effective management.