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Choroid plexus histoplasmoma: clinical, pathologic, and imaging findings
J H Jaster1, F C Dohan, T E Bertorini
1Department of Neurology, Methodist Hospital, Memphis, Tenn, USA.
Abstract:
Histoplasmosis of the choroid plexus has not previously been described. We report its occurrence, as well as its clinical, pathologic, and imaging characteristics in one case. Clinically, our patient's choroid plexus lesion produced encephalopathy and third nerve palsy. On imaging it appeared as a hemorrhage or calcification. Cerebrospinal fluid studies were consistent with a chronic meningeal process uncomplicated by hemorrhage. Stereotactic biopsy of the choroid plexus was required to establish the diagnosis of cerebral histoplasmosis. Pathologic examination also revealed prominent abnormal calcification, which permitted the lesion of masquerade as a hemorrhage on computed tomographic and magnetic resonance images.
Insights
This study describes the first reported case of histoplasmosis affecting the choroid plexus. The rare condition presented with neurological symptoms and unusual imaging findings, requiring biopsy for diagnosis.
Area of Science:
- Neurology
- Infectious Diseases
- Radiology
Background:
- Histoplasmosis is a fungal infection typically affecting the lungs.
- Choroid plexus involvement by Histoplasma is previously undescribed.
- The choroid plexus plays a crucial role in cerebrospinal fluid production and maintaining brain homeostasis.