Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Neo-Darwinian developmental evolution: can we bridge the gap between pattern and process?

M F Palopoli¹, N H Patel

¹Howard Hughes Medical Institute, MC1028, AMB N-101, 5841 South Maryland Avenue, Chicago, Illinois 60637, USA. palo@midway.uchicago.edu

Current Opinion in Genetics & Development

|August 1, 1996

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Hospital and community care costs for people newly diagnosed of living with HIV in London, UK.

AIDS care·2022

Same author

Primary colonic squamous cell carcinoma: a case report and review of the literature.

Annals of the Royal College of Surgeons of England·2020

Same author

Infected Viabahn stent graft in the superficial femoral artery.

European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery·2011

Same author

Haldane's rule and its legacy: Why are there so many sterile males?

Trends in ecology & evolution·2011

Same author

Implication of enterohepatic re-circulation on single dose bioequivalence evaluation of two brands of clonidine hydrochloride tablets in healthy human volunteers.

Indian journal of pharmaceutical sciences·2010

Same author

Lophotrochozoa get into the game: the nodal pathway and left/right asymmetry in bilateria.

Cold Spring Harbor symposia on quantitative biology·2010

Same journal

Temporal trajectories underlying adult neuronal diversity.

Current opinion in genetics & development·2026

Same journal

Transcription regulation of cell fate plasticity - from embryonic development to tissue regeneration.

Current opinion in genetics & development·2026

Same journal

Shared molecular and cellular programs during regeneration of glandular epithelia.

Current opinion in genetics & development·2026

Same journal

Lineage tracing in human cortical development.

Current opinion in genetics & development·2026

Same journal

Cis-regulatory strategies in developmental patterning.

Current opinion in genetics & development·2026

Same journal

GABAergic neuron fate specification and lineage allocation: from development to disorder.

Current opinion in genetics & development·2026

See all related articles

The candidate gene approach in developmental evolution can identify altered pathways but may miss small genetic changes. This method is effective for large-effect genes driving adaptations.

Area of Science:

Evolutionary biology
Developmental biology
Genetics

Background:

Renewed interest in developmental evolution over the past decade.
Candidate gene expression patterns are used to infer conserved or altered genetic pathways in divergent taxa.

Purpose of the Study:

To evaluate the candidate gene approach within the neo-Darwinian paradigm.
To assess the suitability of the candidate gene approach for understanding evolutionary genetic mechanisms.

Main Methods:

Examining gene expression patterns of candidate genes across divergent taxa.
Analyzing the inferred changes in developmental pathways.

Main Results:

The candidate gene approach may not identify small-effect genetic changes underlying adaptations.

Related Experiment Videos

This approach is well-suited for adaptations driven by large-effect genes.

Conclusions:

The candidate gene approach's utility depends on the genetic architecture of adaptations.
It can reveal altered developmental pathways but may not pinpoint specific genetic substitutions for small-effect adaptations.