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Reovirus type 1 associated with meningitis
P J Johansson1, T Sveger, K Ahlfors
1Department of Medical Microbiology, University Hospital of Lund, Sweden.
Scandinavian Journal of Infectious Diseases
|January 1, 1996
Summary
A rare case of meningitis in an infant was linked to reovirus type 1 infection. This study highlights reovirus as a potential cause of central nervous system symptoms in children.
Area of Science:
- Virology
- Pediatric Neurology
- Infectious Diseases
Background:
- Central nervous system (CNS) infections in infants can have severe outcomes.
- Reoviruses are known to cause various illnesses, but their association with CNS disease is less common.
Observation:
- A previously healthy 3-month-old girl presented with meningitis, diarrhea, vomiting, and fever.
- Cerebrospinal fluid (CSF) analysis revealed reovirus-like particles via electron microscopy.
Findings:
- The isolated pathogen from CSF was identified as reovirus type 1 using RNA-gel electrophoresis, immunofluorescence, and virus neutralization.
- Paired sera demonstrated a significant rise in antibodies against the CSF isolate, confirming a reovirus type 1 infection.
Implications:
- This case adds to the limited evidence associating reovirus with CNS symptoms in human infants.
- Further research is warranted to understand the role of reovirus in pediatric neurological disorders.