Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Can early asthma be confirmed by laboratory tests?

T Metso1, K Kilpiö, F Björkstén

  • 1Department of Allergic Diseases, Helsinki University Central Hospital, Finland.

Allergy
|April 1, 1996
PubMed
Summary

Diagnosing asthma symptoms like cough and wheezing can be challenging. Combining lung function tests with eosinophil activation markers significantly improves diagnostic sensitivity, especially with improved sputum analysis.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Allergic Rhinitis and its Impact on Asthma (ARIA) Classes in MASK-air Users.

Journal of investigational allergology & clinical immunology·2025
Same author

Adherence to inhaled corticosteroids and long-acting β2-agonists in asthma: A MASK-air study.

Pulmonology·2023
Same author

From MASK-air and SILAM to CATALYSE (Climate Action To Advance HeaLthY Societies in Europe).

Journal of investigational allergology & clinical immunology·2023
Same author

Rhinitis associated with asthma is distinct from rhinitis alone: The ARIA-MeDALL hypothesis.

Allergy·2023
Same author

Identification by cluster analysis of patients with asthma and nasal symptoms using the MASK-air® mHealth app.

Pulmonology·2022
Same author

Treatment of allergic rhinitis during and outside the pollen season using mobile technology. A MASK study.

Clinical and translational allergy·2020

Area of Science:

  • Pulmonology
  • Allergy and Immunology
  • Diagnostic Medicine

Background:

  • Asthma diagnosis in patients with recent onset symptoms (<1 year) like cough, sputum, and wheezing presents diagnostic challenges.
  • Standard diagnostic tests, including histamine challenge, show limited sensitivity in early-stage asthma detection.

Purpose of the Study:

  • To evaluate the diagnostic performance of individual and combined laboratory tests for asthma in patients with suggestive symptoms.
  • To determine if combining lung function tests with markers of eosinophil activation enhances diagnostic accuracy.

Main Methods:

  • Assessed the sensitivity of various laboratory tests in 23 patients presenting with asthma-like symptoms.
  • Evaluated individual tests like histamine challenge, peak expiratory flow, sputum eosinophil cationic protein (ECP), and serum ECP.

Related Experiment Videos

  • Analyzed the cumulative sensitivity achieved by combining different tests.

    • Main Results:

    • Histamine challenge alone demonstrated a sensitivity of 48%.
    • Adding peak expiratory flow increased sensitivity to 65%.
    • Further addition of sputum ECP and serum ECP elevated sensitivity to 74% and 78%, respectively.

    Conclusions:

    • A combination of lung function tests and eosinophil activation markers provides fair to good sensitivity for diagnosing early-stage asthma.
    • Further improvements in sputum analysis may enhance diagnostic sensitivity for asthma.