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Development of new immunocontraceptives-industrial perspective
1Research Laboratories of Schering AG, Germany.
Summary
Developing non-hormonal contraceptives remains a challenge. Research into immunological targets like the zona pellucida and sperm offers promising avenues for effective fertility control methods.
Area of Science:
- Reproductive biology
- Immunology
- Contraceptive development
Background:
- Contraception has a long history, with oral hormonal contraceptives emerging in the late 1950s/early 1960s.
- Despite advances, effective non-hormonal contraceptives comparable to hormonal methods in efficacy, safety, and acceptance are still lacking.
Purpose of the Study:
- To explore immunological interference with fertilization as a target for novel contraceptive development.
- To identify potential targets for both female and male fertility control.
Main Methods:
- Investigating the zona pellucida as an ideal target due to its role in mammalian egg surrounding.
- Examining sperm as a target for contraceptive strategies.
Main Results:
- The zona pellucida is identified as a promising target for immunological contraception.
- Sperm are also considered a target, though male contraceptive development faces challenges.
Conclusions:
- There is a need for a diverse range of contraceptive methods to meet varied global needs.
- Further research into non-hormonal contraceptives, including male options, is crucial for comprehensive fertility control.