Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Heart rate variability in hypertensive subjects

G Piccirillo1, M R Munizzi, F L Fimognari

  • 1Cattedra di Geriatria, Policlinico Umberto I, Università di Roma La Sapienza, Italy.

International Journal of Cardiology
|March 1, 1996
PubMed
Summary

Hypertension is linked to increased sympathetic nervous system activity. This study found that heightened sympathetic markers in hypertensive individuals correlate with left ventricular mass, suggesting a connection to heart structure changes.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Time and Frequency Repolarization Domains in Elderly Candidates to Transcatheter Aortic Valve Replacement.

La Clinica terapeutica·2023
Same author

Short-Period Temporal Dispersion Repolarization Markers in Elderly Patients with Decompensated Heart Failure.

La Clinica terapeutica·2022
Same author

Controlled and tuneable drug release from electrospun fibers and a non-invasive approach for cytotoxicity testing.

Scientific reports·2019
Same author

Changes in left ventricular repolarization after short-term testosterone replacement therapy in hypogonadal males.

Journal of endocrinological investigation·2019
Same author

Aging and Adherence to the Mediterranean Diet: Relationship with Cardiometabolic Disorders and Polypharmacy.

The journal of nutrition, health & aging·2018
Same author

Fall prevention in the young old using an exoskeleton human body posturizer: a randomized controlled trial.

Aging clinical and experimental research·2016

Area of Science:

  • Cardiology
  • Autonomic Neuroscience
  • Hypertension Research

Background:

  • Hypertension is frequently associated with sympathetic nervous system hyperactivity.
  • Adrenergic receptor stimulation is known to induce left ventricular hypertrophy (LVH).
  • Understanding autonomic nervous system (ANS) function is crucial in managing hypertension and its cardiac consequences.

Purpose of the Study:

  • To compare autonomic nervous system function in mild hypertensive subjects versus normotensive controls.
  • To investigate the relationship between heart rate variability (HRV) spectral indices and left ventricular mass index (LVMI) in hypertension.
  • To assess changes in sympathovagal balance during sympathetic stress (head-up tilt).

Main Methods:

  • Power spectrum analysis of heart rate variability using an autoregressive algorithm.

Related Experiment Videos

  • Assessment of four spectral frequency domains: total power, high-frequency (vagal activity), low-frequency (sympathetic activity), and very-low-frequency power.
  • Measurement of left ventricular mass index via M-mode echocardiography and comparison with spectral densities.

    • Main Results:

    • Hypertensive subjects exhibited significantly higher low-frequency power and low-high frequency ratio compared to normotensive controls.
    • Hypertensive individuals showed a diminished capacity for sympathovagal balance adjustment during head-up tilt.
    • Multiple regression analysis revealed that LVMI was independently associated with body mass index, very-low frequency, low frequency, low-high frequency ratio, and systolic blood pressure.

    Conclusions:

    • Findings confirm enhanced sympathetic nervous system activity in individuals with mild hypertension.
    • A significant association exists between left ventricular mass index and spectral indices reflecting sympathetic activation.
    • Autonomic dysfunction, particularly sympathetic hyperactivity, may play a role in the cardiac structural changes observed in hypertension.