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Inhibition of lipid peroxidation by sesquiterpenoid in Heterotheca inuloides
H Haraguchi1, T Saito, H Ishikawa
1Faculty of Engineering, Fukuyama University, Japan.
The Journal of Pharmacy and Pharmacology
|April 1, 1996
Abstract:
A sesquiterpenoid, 7-hydroxy-3,4-dihydrocadalin, isolated from a Mexican medicinal plant Heterotheca inuloides was evaluated as an antioxidant. This sesquiterpenoid inhibited mitochondrial and microsomal lipid peroxidation induced by Fe(III)-ADP/NADH or Fe(III)-ADP/NADPH. Furthermore, 7-hydroxy-3,4-dihydrocadalin protected red cells against oxidative haemolysis. This sesquiterpene was thus shown to be effective in protecting biological systems against oxidative stresses.