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Inhalational drug delivery from seven different spacer devices
1Department of Child Health, University of Leicester, Leicester Royal Infirmary, UK.
Thorax
|August 1, 1996
Summary
Large volume spacer devices significantly improve drug delivery for disodium cromoglycate and salbutamol compared to smaller devices. Spacer effectiveness varies by medication, necessitating individual evaluation for optimal inhaled therapy.
Area of Science:
- Respiratory Medicine
- Pharmaceutical Sciences
- Drug Delivery Systems
Background:
- Metered dose inhalers (MDIs) are commonly used for respiratory conditions.
- Spacer devices are often used with MDIs to improve drug delivery.
- Variability in spacer performance exists.
Purpose of the Study:
- To compare the in vitro drug output of seven different spacer devices.
- To evaluate spacer performance with three inhaled medications: disodium cromoglycate (DSCG), salbutamol, and budesonide.
Main Methods:
- A multistage liquid impinger (MSLI) was used for in vitro testing.
- MDIs were actuated directly or via seven different spacer devices.
- Drug amounts were quantified in various particle size ranges.
Main Results:
- Large volume spacers (Fisonair, Nebuhaler, Volumatic) delivered more DSCG and salbutamol in small particles (<5 microns) than MDI alone.
- Smaller spacers showed variable performance, with some decreasing drug delivery.
- Spacer differences were less pronounced for budesonide.
Conclusions:
- Spacer device choice significantly impacts inhaled drug availability.
- Large volume spacers generally offer superior delivery for DSCG and salbutamol.
- Individual evaluation of spacer-drug combinations is crucial for effective patient treatment.