Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Microscopic polyangiitis: clinical aspects and treatment

F Lhote1, P Cohen, T Généreau

  • 1Service de Médecine Interne, Hôpital Delafontaine, Saint-Denis.

Annales De Medecine Interne
|January 1, 1996
PubMed
Summary

Microscopic polyangiitis (MPA) is a small-vessel vasculitis primarily affecting kidneys and lungs. Diagnosis relies on clinical signs, ANCA testing, and distinguishing it from polyarteritis nodosa (PAN).

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A descriptive study of IgG4-related disease in children and young adults.

Autoimmunity reviews·2022
Same author

[Inability to walk in a 41-year-old man].

La Revue de medecine interne·2015
Same author

[Cerebral infarction, a complication of paroxysmal nocturnal haemoglobinuria].

Revue neurologique·2007
Same author

Subacute bacterial endocarditis presenting as polymyalgia rheumatica or giant cell arteritis.

Clinical and experimental rheumatology·2006
Same author

[Floating aortic thrombosis: an uncommon cause of systemic emboli].

La Revue de medecine interne·2005
Same author

Digital ulcers in systemic sclerosis: prevention by treatment with bosentan, an oral endothelin receptor antagonist.

Arthritis and rheumatism·2004

Area of Science:

  • Rheumatology
  • Nephrology
  • Pulmonology

Background:

  • Microscopic polyangiitis (MPA) is a distinct systemic necrotizing vasculitis affecting small vessels.
  • It is differentiated from polyarteritis nodosa (PAN) by the absence of granulomata and specific organ involvement patterns.
  • MPA commonly presents with renal and pulmonary manifestations, significantly impacting patient morbidity and mortality.

Purpose of the Study:

  • To summarize the key clinical, histological, and serological features of microscopic polyangiitis.
  • To highlight diagnostic criteria that differentiate MPA from similar vasculitic conditions like PAN.
  • To discuss the prognostic factors and therapeutic strategies for MPA management.

Main Methods:

  • Review of clinical presentations, diagnostic markers, and treatment outcomes for MPA patients.

Related Experiment Videos

  • Comparison of MPA characteristics with those of polyarteritis nodosa (PAN).
  • Analysis of laboratory findings including antineutrophil cytoplasm antibodies (ANCA) and imaging data.

    • Main Results:

    • MPA primarily affects small vessels, with renal (glomerulonephritis) and pulmonary (hemorrhage, interstitial disease) involvement being most common.
    • Antineutrophil cytoplasm antibodies (ANCA), particularly anti-myeloperoxidase (MPO), are present in 75% of patients.
    • Musculoskeletal, cutaneous, and gastrointestinal symptoms are also frequently observed, though peripheral neuropathy is less common than in PAN.

    Conclusions:

    • Microscopic polyangiitis is characterized by small-vessel vasculitis with prominent renal and lung disease.
    • Diagnostic differentiation from PAN is crucial and relies on ANCA status, organ involvement, and angiographic findings.
    • Corticosteroids and immunosuppressive agents like cyclophosphamide are the mainstay of treatment, with prolonged therapy often necessary due to high relapse rates and renal involvement.