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Effect of iodixanol on in vitro bleeding time
L G Melton1, K M Muga, D A Gabriel
1Department of Medicine, University of North Carolina School of Medicine, Chapel Hill 27599, USA.
Academic Radiology
|May 1, 1996
Summary
Dimeric iodixanol, a nonionic contrast medium, significantly prolonged in vitro bleeding time in whole blood. This indicates it affects hemostasis similarly to nonionic monomeric contrast agents.
Area of Science:
- Radiology
- Hematology
- Biomedical Engineering
Background:
- Ionic radio contrast media (CM) can exhibit anticoagulant properties.
- Nonionic monomeric CM are known to be less anticoagulant than ionic CM.
- Iodixanol is a nonionic dimeric contrast medium with potential anticoagulant effects.
Purpose of the Study:
- To investigate the anticoagulant potential of iodixanol, a nonionic dimeric contrast medium.
- To compare the anticoagulant effects of iodixanol with nonionic monomeric CM.
- To determine if the dimeric structure of iodixanol influences its anticoagulant activity.
Main Methods:
- Utilized a global screening device simulating physiologic flow conditions.
- Assessed the impact of iodixanol on in vitro bleeding time (IVBT).
- Employed a hollow fiber device to monitor hemostatic system's ability to form platelet plugs.
Main Results:
- Iodixanol (25% CM/blood, v/v) significantly increased mean IVBT to 18.74 minutes from a baseline of 4.24 minutes.
- The study involved 20 healthy donors.
- Results demonstrated a marked prolongation of bleeding time in the presence of iodixanol.
Conclusions:
- Nonionic dimeric iodixanol impacts in vitro bleeding time similarly to nonionic monomeric CM.
- The dimeric structure of iodixanol does not alter its anticoagulant profile compared to monomeric agents.
- Iodixanol exhibits anticoagulant properties comparable to ioversol, iopamidol, and iohexol.