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Cell adhesion molecules in HTLV-I infection
T Uchiyama1, T Ishikawa, A Imura
1Research Center for Immunodeficiency Virus, Kyoto University, Japan.
Cell adhesion molecules expressed on the cell surface of leukemic cells and on vascular endothelial cells may play a key role in trafficking, localization, and infiltration of leukemic cells in adult T-cell leukemia (ATL). The predominant adhesion pathway between ATL cells or human T-cell leukemia virus type I (HTLV-I)-infected cell lines and human umbilical vein endothelial cells (HUVECs) is an E-selectin-mediated pathway as determined by studies using adhesion-blocking monoclonal antibodies, although fresh leukemic cells and HTLV-I-infected cell lines also expressed LFA-I, VLA-4, L-selectin, and CD44. Our study also strongly suggested the presence of adhesion pathway(s) mediated by as yet unknown cell adhesion molecule(s), to which we have recently developed monoclonal antibodies.
Cell adhesion molecules expressed on the cell surface of leukemic cells and on vascular endothelial cells may play a key role in trafficking, localization, and infiltration of leukemic cells in adult T-cell leukemia (ATL). The predominant adhesion pathway between ATL cells or human T-cell leukemia virus type I (HTLV-I)-infected cell lines and human umbilical vein endothelial cells (HUVECs) is an E-selectin-mediated pathway as determined by studies using adhesion-blocking monoclonal antibodies, although fresh leukemic cells and HTLV-I-infected cell lines also expressed LFA-I, VLA-4, L-selectin, and CD44. Our study also strongly suggested the presence of adhesion pathway(s) mediated by as yet unknown cell adhesion molecule(s), to which we have recently developed monoclonal antibodies.