Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Solid state characterization of dehydroepiandrosterone

L C Chang1, M R Caira, J K Guillory

  • 1College of Pharmacy, University of Iowa, Iowa City 52242, USA.

Journal of Pharmaceutical Sciences
|October 1, 1995
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Incidence and mortality of sepsis in Hong Kong between 2009 and 2018 based on electronic health records: abridged secondary publication.

Hong Kong medical journal = Xianggang yi xue za zhi·2024
Same author

Host Genetic Associations with Salivary Microbiome in Oral Cancer.

Journal of dental research·2021
Same author

Active Volcanism Revealed from a Seismicity Conduit in the Long-resting Tatun Volcano Group of Northern Taiwan.

Scientific reports·2020
Same author

First Report of Association of Mucor circinelloides on Noni (Morinda citrifolia) in Hawaii.

Plant disease·2019
Same author

Crystal form conversion of nevirapine solvates subjected to elevated temperature and humidity: a qualitative study.

Die Pharmazie·2018
Same author

Strengthening teachers' abilities to implement a vision health program in Taiwanese schools.

Health education research·2017
Same journal

Green, renewable, or low-carbon? A framework for informed solvent selection in pharmaceutical sciences.

Journal of pharmaceutical sciences·2026
Same journal

Theranostic potential of ramucirumab functionalized magnetoliposomes for targeted delivery of sorafenib and MRI.

Journal of pharmaceutical sciences·2026
Same journal

Intranasal mucoadhesive chitosan microspheres of ranolazine: Formulation, design, and pharmacokinetic evaluation.

Journal of pharmaceutical sciences·2026
Same journal

Evolving landscape of drug development for pediatric rare diseases-from successes to strategies for addressing unmet needs.

Journal of pharmaceutical sciences·2026
Same journal

A mathematical framework for predicting tablet weight variability from blend particle size distribution and tooling geometry.

Journal of pharmaceutical sciences·2026
Same journal

Recrystallization can stop nitrosamine formation in ranitidine hydrochloride.

Journal of pharmaceutical sciences·2026
See all related articles

This study characterized seven solid forms of a compound, revealing their stability and dissolution properties. Form I is the most stable polymorph, but all forms convert to the stable monohydrate (form S2) under humid conditions.

Area of Science:

  • Solid-state chemistry
  • Materials science
  • Pharmaceutical sciences

Background:

  • Understanding the solid-state properties of active pharmaceutical ingredients is crucial for drug development.
  • Polymorphism and solvate formation significantly impact a compound's physical and chemical behavior.

Purpose of the Study:

  • To isolate and characterize various solid forms of a compound.
  • To determine the thermodynamic stability and dissolution rates of different polymorphs and solvates.
  • To investigate phase transformations and their implications for formulation.

Main Methods:

  • X-ray powder diffractometry (XRPD) for structural identification.
  • Differential scanning calorimetry (DSC) and hot stage microscopy for thermal analysis.

Related Experiment Videos

  • Solution calorimetry and dissolution rate measurements for thermodynamic and kinetic studies.

    • Main Results:

    • Seven solid forms were identified: three polymorphs (I-III), one monohydrate (S2), and three new solvates (S1, S3, S4).
    • Polymorphs I-III exhibit a monotropic relationship with decreasing stability: I > II > III.
    • Only forms I and S4 showed reproducible DSC thermograms; others underwent phase transformations.
    • All forms converted to the stable monohydrate (S2) during dissolution studies, indicating sensitivity to moisture.

    Conclusions:

    • The stable form I has a higher dissolution rate than metastable forms II and III.
    • Moisture control is critical in solid formulations to prevent conversion to the stable monohydrate (S2).
    • XRPD is effective for purity determination, detecting contaminants down to 5%.