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Granulocyte transfusions. Time for a second look

S J Chanock1, J B Gorlin

  • 1National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.

Infectious Disease Clinics of North America
|June 1, 1996
PubMed
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Granulocyte transfusions for neutropenic infections are being re-evaluated due to improved collection methods and growth factor use. This review examines their potential role in supporting patients with low white blood cell counts.

Area of Science:

  • Hematology
  • Transfusion Medicine
  • Oncology Supportive Care

Background:

  • Granulocyte transfusions were historically controversial due to logistical challenges, toxicity, and limited efficacy.
  • These transfusions were largely abandoned but are now being reconsidered for neutropenic patients.

Purpose of the Study:

  • To review the current data on granulocyte transfusions.
  • To assess the renewed potential of granulocyte transfusions in managing infections in neutropenic hosts.

Main Methods:

  • Review of existing literature and data on granulocyte transfusions.
  • Consideration of recent advancements in hematopoietic growth factors and apheresis technology.

Main Results:

  • Recombinant hematopoietic growth factors (e.g., G-CSF, GM-CSF) enhance granulocyte yield.

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  • Improvements in cell collection processes increase efficiency and feasibility.

    • Conclusions:

    • Advances in donor cell mobilization and collection techniques warrant a re-evaluation of granulocyte transfusions.
    • Further studies are needed to define the precise role of granulocyte transfusions in neutropenic patients.