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Primary localized nasopharyngeal amyloidosis. A case report
S Domínguez1, P Wienberg, P Clarós
1E.N.T. Department, Hospital Universitari Sant Joan De Deu, Barcelona, Spain.
Summary
Localized amyloidosis of the nasopharynx is rare, especially in children. This case highlights the importance of considering this condition in pediatric patients with nasal obstruction and bleeding, with surgical intervention showing positive outcomes.
Area of Science:
- Otolaryngology
- Pathology
- Oncology
Background:
- Primary localized amyloidosis is an uncommon condition affecting the nasopharynx.
- Pediatric cases are exceptionally rare, with only two reported instances in the literature.
Observation:
- A 13-year-old girl presented with nasal obstruction and oral bleeding.
- Physical examination revealed a nasopharyngeal mass and left soft palate involvement.
- Diagnosis was confirmed via biopsy and histopathologic examination, identifying amyloid light chains (AL).
Findings:
- Surgical resection was the primary treatment modality.
- Immunohistochemical analysis confirmed AL-type amyloidosis.
- No recurrence was observed at the 9-month follow-up.
Implications:
- Localized nasopharyngeal amyloidosis should be included in the differential diagnosis for pediatric nasal obstruction, epistaxis, and otitis media with effusion (glue ear).
- Otolaryngologists must be aware of this rare entity for accurate diagnosis and treatment planning.
- Early recognition and appropriate management are crucial for favorable patient outcomes.