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The RING finger domain: a recent example of a sequence-structure family
1Department of Biochemistry, Faculty of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada.
Current Opinion in Structural Biology
|June 1, 1996
Abstract:
In the past 18 months, two RING finger structures have been solved. They represent the first reported structures for this novel zinc-binding sequence motif. Both structures are significantly different from other zinc-binding domains, in terms of both their zinc-ligation scheme and their three-dimensional structures. The RING finger domain appears to be a convenient scaffold which can be altered to provide functional specificity in those proteins that contain the motif.