Oligonucleotide directed triple helix formation
Related Experiment Video
Updated: Nov 4, 2026

Sequence-specific and Selective Recognition of Double-stranded RNAs over Single-stranded RNAs by Chemically Modified Peptide Nucleic Acids
Published on: September 21, 2017
J S Sun1, T Garestier, C Hélène
1Laboratoire de Biophysique, Muséum National d'Histoire Naturelle, INSERM U201, Centre National de la Recherche Scientifique, URA481, Paris, France. biophy@mnhn.fr
Abstract:
Oligonucleotide directed triple helix formation allows the sequence-specific recognition of the major groove of double-helical DNA. Recently synthesized base analogs and backbones, such as N3'-->P5' phosphoramidates, allow stable triplexes to be formed under physiological conditions. However, it remains a challenge to design new oligomers that would extend the range of recognition sequences (which are still limited to oligopurine-rich tracts). Oligonucleotide directed triple helix formation could be used to control biological processes such as transcription and replication. Three-stranded structures formed during recombination processes have been further characterized.
Related Concept Videos
Nucleic Acid Structure
DNA Structure
DNA has a double-helix structure. The...
Single-Strand DNA Binding Proteins
Protein Organization
Protein Organization
The primary structure of a protein is its amino acid sequence.
Homologous Recombination
The DNA Helix

