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Induction of macrophage antiprotozoal activity by monocyte chemotactic and activating factor
S B Mannheimer1, J Hariprashad, M Y Stoeckle
1Division of Infectious Diseases, Cornell University Medical College, New York, NY 10021, USA.
Abstract:
To determine if monocyte chemotactic and activating factor (MCAF) induces intracellular antimicrobial activity, human monocyte-derived macrophages were treated with MCAF and challenged with Toxoplasma gondii and Leishmania donovani. Pretreatment with MCAF induced macrophages to inhibit protozoal replication by approximately 50%. These findings suggest a potential host defense role for MCAF in the inflammatory response to intracellular pathogens.
