Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Antiarrhythmic mechanisms during exercise

D J Paterson1

  • 1University Laboratory of Physiology, Oxford, United Kingdom.

Journal of Applied Physiology (Bethesda, Md. : 1985)
|June 1, 1996
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Pure CO<sub>2</sub> and impure CO<sub>2</sub>-SO<sub>2</sub>-NO-O<sub>2</sub> reactions with carbon storage site underlying seals: Coaly mudstones and carbonate cemented sandstones.

The Science of the total environment·2025
Same author

Neurocardiology: translational advancements and potential.

The Journal of physiology·2024
Same author

Neurocardiac regulation: from cardiac mechanisms to novel therapeutic approaches.

The Journal of physiology·2018
Same author

Visualising coordination chemistry: fluorescence X-ray absorption near edge structure tomography.

Chemical communications (Cambridge, England)·2016
Same author

Integrating microfluidic generation, handling and analysis of biomimetic giant unilamellar vesicles.

Lab on a chip·2014
Same author

Telemetric analysis of haemodynamic regulation during voluntary exercise training in mouse models.

Experimental physiology·2011
Same journal

Intracranial vasomotor and blood flow responses to light intensity aerobic exercise in young adults: a 4D flow MRI study.

Journal of applied physiology (Bethesda, Md. : 1985)·2026
Same journal

Comparative assessments of the COSMED adaptive mixing chamber vs. breath-by-breath methods for oxygen uptake measurements in recreationally active adults.

Journal of applied physiology (Bethesda, Md. : 1985)·2026
Same journal

Can we assess exercise metabolism from skin? Metabolomic profiles in skin dialysate collected during exercise.

Journal of applied physiology (Bethesda, Md. : 1985)·2026
Same journal

Characterization of intracranial pressure variations in ventricular and subarachnoid spaces of the rat brain.

Journal of applied physiology (Bethesda, Md. : 1985)·2026
Same journal

Biomedical Research in an Age of Anxiety: Four Papers for Worried Minds.

Journal of applied physiology (Bethesda, Md. : 1985)·2026
Same journal

Training status augments mechanisms of rapid‑onset vasodilation in healthy young adults.

Journal of applied physiology (Bethesda, Md. : 1985)·2026
See all related articles

Vigorous exercise causes chemical changes in the heart that normally protect against arrhythmia. However, these protective mechanisms can fail, especially post-exercise or with underlying heart disease, increasing cardiac risks.

Area of Science:

  • Cardiovascular Physiology
  • Exercise Science
  • Cardiac Electrophysiology

Background:

  • Exercise induces significant changes in plasma potassium (K+), pH, and catecholamines.
  • These physiological shifts, if occurring at rest, increase arrhythmia and cardiac arrest risk.
  • The heart's protective mechanisms against exercise-induced chemical stress are not fully understood.

Purpose of the Study:

  • To investigate the protective mechanisms of the heart against chemical stress during exercise.
  • To understand the interplay between hyperkalemia, acidosis, and catecholamines in cardiac protection.
  • To explore the risks associated with the post-exercise period and underlying cardiac conditions.

Main Methods:

  • Review of existing literature on exercise physiology and cardiac electrophysiology.

Related Experiment Videos

  • Analysis of the effects of hyperkalemia, acidosis, and catecholamines on cardiac function in various models (isolated hearts, in vivo, myocytes).
  • Examination of epidemiological data linking exercise to sudden cardiac death and myocardial infarction.

    • Main Results:

    • A mutual antagonism between catecholamines, hyperkalemia, and acidosis provides a collective antiarrhythmic effect during exercise.
    • Catecholamines can counteract the arrhythmogenic effects of hyperkalemia and acidosis.
    • The protective effect is diminished in hearts with ischemia or infarction.
    • The post-exercise period, with low K+ and high adrenergic tone, may pose the greatest risk.

    Conclusions:

    • The heart possesses a complex protective mechanism against exercise-induced chemical stress.
    • Disruption of this mechanism, particularly in individuals with coronary artery disease or during the post-exercise phase, can increase the risk of sudden cardiac death.
    • Regular physical activity generally reduces cardiac death risk, but vigorous exercise can be a trigger in susceptible individuals.