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Related Experiment Videos

Triclosan: applications and safety

H N Bhargava1, P A Leonard

  • 1Division of Pharmaceutical Sciences, Massachusetts College of Pharmacy and Allied Health Sciences, Boston 02115, USA.

American Journal of Infection Control
|June 1, 1996
PubMed
Summary

Triclosan, a broad-spectrum antimicrobial, is safe for personal care products and shows promise for oral care applications like plaque control. Its established safety profile supports its widespread use.

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Area of Science:

  • Antimicrobial agents
  • Personal care product ingredients
  • Dermatology

Background:

  • Triclosan (2,4,4'-trichloro-2'-hydroxydiphenyl ether) is a widely used nonionic, broad-spectrum antimicrobial agent.
  • Its favorable safety profile has led to its incorporation into numerous personal care products.
  • Triclosan demonstrates moderate skin substantivity, providing a residual antimicrobial effect.

Purpose of the Study:

  • To review the safety and applications of triclosan.
  • To evaluate its efficacy in personal care products and emerging oral care uses.

Main Methods:

  • Review of existing toxicological data (acute, subacute/subchronic, chronic toxicity).
  • Assessment of human safety data regarding skin irritation and sensitization.
  • Evaluation of triclosan's application in personal care and oral hygiene products.

Main Results:

  • Triclosan is not an acute oral toxicant, carcinogen, mutagen, or teratogen.
  • While high exposure can cause dermal irritation in animals, it rarely causes skin issues in humans within formulated products.
  • Triclosan is effective for plaque control in oral dentifrices, approved in Canada and Europe.

Conclusions:

  • Triclosan possesses a favorable safety profile for use in personal care products.
  • Its application is expanding into oral hygiene, demonstrating efficacy in plaque control.
  • Further investigation in the United States supports its potential in oral dentifrices.

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