Related Experiment Video
Updated: Jul 10, 2026
07:08
In Situ Synthesis of Gold Nanoparticles without Aggregation in the Interlayer Space of Layered Titanate Transparent Films
Published on: January 17, 2017
Contact allergy to gold sodium thiosulfate
R A Sabroe1, L A Sharp, R D Peachey
1Department of Dermatology, Bristol Royal Infirmary, UK.
Contact Dermatitis
|May 1, 1996
Summary
Gold sodium thiosulfate (GST) patch testing identified allergies in 13% of contact dermatitis patients. Positive reactions were linked to eczema on ring fingers and neck, suggesting gold allergy concerns.
Area of Science:
- Dermatology
- Allergology
- Contact Dermatitis
Background:
- Contact dermatitis is a common skin condition.
- Gold jewelry is frequently used and can cause allergic reactions.
- Gold sodium thiosulfate (GST) is a common allergen in gold compounds.
Purpose of the Study:
- To investigate the prevalence of gold sodium thiosulfate (GST) allergy in patients with contact dermatitis.
- To identify clinical features associated with GST allergy.
Main Methods:
- 100 consecutive patients attending a contact dermatitis clinic were patch tested.
- Patients were tested with gold sodium thiosulfate (GST).
- Results were analyzed for correlations with demographics, nickel sensitivity, and eczema location.
Main Results:
- 13% of patients had a positive patch test to GST.
- Positive GST reactions were more common in females and those with pierced ears.
- Eczema on the ring fingers and neck was significantly more frequent in GST-positive patients.
- Nickel sensitivity was highly prevalent (33%) in the overall patient group.
Conclusions:
- Gold sodium thiosulfate (GST) is a relevant allergen in contact dermatitis.
- Clinical signs like eczema on fingers and neck may indicate gold allergy.
- Further investigation into gold allergy diagnosis and management is warranted.
Related Concept Videos
02:06Allergic Reactions
Overview
02:33Preparation and Reactions of Thiols
Thiols are prepared using the hydrosulfide anion as a nucleophile in a nucleophilic substitution reaction with alkyl halides. For instance, bromobutane reacts with sodium hydrosulfide to give butanethiol.
01:27Allergic Drug Reactions
Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing numerous...
01:30Drug Toxicity: Allergic Reactions
Drug-related allergies are immune-mediated responses triggered by the administration of pharmacological agents. These hypersensitivity reactions are classified based on the immune mechanisms involved. The four primary types—Type I, II, III, and IV—are mediated by different immunological pathways and exhibit distinct clinical manifestations.Type I Hypersensitivity/ IgE-Mediated Reactions: Immunoglobulin E (IgE) immediately mediates Type I hypersensitivity reactions. Upon initial exposure to a...
01:30Allergic Reactions: Anaphylaxis
Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin, heparin),...
01:29Hypersensitivity Reactions: Delayed Hypersensitivity Reactions
Delayed-Type Hypersensitivity (DTH), or Type IV hypersensitivity, is a cell-mediated immune response. It occurs when T cells, rather than antibodies, mediate a reaction to specific antigens. It is characterized by a delayed onset (1-2 days) and involves the recruitment of macrophages to the inflammation site.The initiation of a DTH response begins with the sensitization of T cells. During this phase, which lasts at least 1-2 weeks, antigen-specific T cells are activated, clonally expanded, and...