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[Risk factor, natural history and prognosis of the patients with arteriosclerosis obliterans]
Insights
Understanding risk factors and the natural history of arteriosclerosis obliterans (ASO) is key for effective treatment. ASO patients face higher mortality, primarily from cardiovascular and cerebrovascular diseases, necessitating comprehensive evaluation.
Area of Science:
- Vascular Medicine
- Cardiovascular Disease Epidemiology
Context:
- Arteriosclerosis Obliterans (ASO) is a significant vascular condition.
- Identifying and managing ASO risk factors is crucial for patient outcomes.
Purpose:
- To emphasize the importance of understanding ASO risk factors and natural history.
- To highlight the increased mortality and systemic nature of ASO.
Summary:
- Major risk factors for ASO include hypercholesterolemia, hypertension, and smoking.
- Minor factors include diabetes, obesity, hypertriglyceridemia, low HDL, aging, and gender.
- ASO patients exhibit a poorer prognosis and higher mortality rates, often due to coronary and cerebrovascular diseases.
Impact:
- Informs optimal treatment strategies for arteriosclerosis obliterans.
- Underscores the need for systemic evaluation in ASO patient management.
- Contributes to understanding the long-term prognosis and mortality associated with ASO.
Abstract:
A sufficient understanding of the risk factor and the natural history of arteriosclerosis obliterans, ASO, is essential for selecting the optimal treatment for this condition. Hypercholesterolemia, hypertension and cigarette smoking have been identified as independent major risk factors of ASO, and diabetics, obesity, hypertrigriceridemia, low HDL-cholesterol level, aging, gender, etc, as minor factors. The patients with ASO often have multiple risk factors, synergistically accelerating the disease progression. Recent objective studies on natural history of claudicants have demonstrated a more morbid prognosis, especially in the patients with disabling claudication, than that outlined by previous historical studies. Mortality rates for ASO patients in long-term follow-up have revealed to be significantly higher than those observed in control groups. The causes of death are mostly arteriosclerotic vascular disease, particularly coronary artery and cerebrovascular diseases, which indicate the significance of the systemic evaluation in treating patients with ASO.