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Clomipramine and sexual function in men with premature ejaculation and controls
S M Haensel1, D L Rowland, K T Kallan
1Department of Endocrinology and Reproduction, Erasmus University, Rotterdam, The Netherlands.
The Journal of Urology
|October 1, 1996
Summary
Clomipramine effectively increased ejaculation latency in men with primary premature ejaculation. This treatment did not show significant effects in controls or men with premature ejaculation and erectile dysfunction.
Area of Science:
- Sexual medicine
- Pharmacology
Background:
- Premature ejaculation (PE) is a common sexual dysfunction.
- Effective treatment options for PE are continuously being researched.
Purpose of the Study:
- To evaluate the efficacy of clomipramine as an as-needed medication for increasing ejaculation latency in men with premature ejaculation.
- To compare the effects in men with primary PE versus those with PE and erectile dysfunction, as well as in control subjects.
Main Methods:
- A prospective, double-blind, placebo-controlled, crossover study design.
- Inclusion of 8 patients with primary PE, 6 with PE and erectile dysfunction, and 8 controls.
- Administration of 25 mg clomipramine or placebo as needed, 12-24 hours before sexual activity, over two 3-week periods.
Main Results:
- Clomipramine significantly increased ejaculation latency from approximately 2 to 8 minutes in men with primary PE.
- No significant effects on ejaculation latency were observed in controls or men with PE and erectile dysfunction.
- Clomipramine therapy improved ejaculatory control, sexual satisfaction, and relationship satisfaction in men with primary PE.
Conclusions:
- As-needed 25 mg clomipramine is an effective treatment for increasing ejaculation latency in men with primary premature ejaculation.
- Clomipramine was not effective in men with premature ejaculation and co-existing erectile dysfunction.