Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Tumor necrosis factor: function, release and clearance

M H Bemelmans1, L J van Tits, W A Buurman

  • 1Department of Surgery, University Hospital Maastricht, The Netherlands.

Critical Reviews in Immunology
|January 1, 1996
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Metabolic improvement in obese patients after duodenal-jejunal exclusion is associated with intestinal microbiota composition changes.

International journal of obesity (2005)·2019
Same author

Tumor Necrosis Factor: Function, Release and Clearance.

Critical reviews in immunology·2018
Same author

Doppler-guided goal-directed fluid therapy does not affect intestinal cell damage but increases global gastrointestinal perfusion in colorectal surgery: a randomized controlled trial.

Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland·2017
Same author

TUB gene expression in hypothalamus and adipose tissue and its association with obesity in humans.

International journal of obesity (2005)·2017
Same author

Progress towards non-invasive diagnosis and follow-up of celiac disease in children; a prospective multicentre study to the usefulness of plasma I-FABP.

Scientific reports·2017
Same author

Relation between postoperative ileus and anastomotic leakage after colorectal resection: a post hoc analysis of a prospective randomized controlled trial.

Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland·2016

Tumor Necrosis Factor (TNF) circulates in bioactive and inactive forms. Soluble TNF receptors inactivate and clear TNF, with the kidney being the primary organ for TNF clearance.

Area of Science:

  • Immunology
  • Cell Biology
  • Physiology

Background:

  • Tumor Necrosis Factor (TNF) is a key cytokine involved in disease pathophysiology.
  • TNF exists in both bioactive and immunologically detectable (inactive) forms with distinct clearance rates.
  • Inactivation mechanisms include proteolytic degradation or binding by specific proteins.

Purpose of the Study:

  • To review the function, release, and clearance of TNF.
  • To focus on TNF inactivation mediated by TNF-binding proteins, specifically soluble TNF receptors.
  • To highlight the role of the kidney and liver in TNF clearance.

Main Methods:

  • Review of recent scientific literature on TNF and its binding proteins.
  • Analysis of data concerning the kinetics and clearance pathways of different TNF forms.

Related Experiment Videos

  • Discussion of the physiological roles of soluble TNF receptors (P55 and P75).

    • Main Results:

    • Soluble TNF receptors (P55 and P75), cleaved from cell membranes, bind and inactivate TNF.
    • These soluble receptors are crucial for both TNF inactivation and clearance.
    • The kidney is identified as the principal organ for TNF clearance, followed by the liver.

    Conclusions:

    • Soluble TNF receptors play a critical role in regulating TNF activity and elimination.
    • Kidneys and liver are the primary organs responsible for clearing TNF from circulation.
    • Understanding TNF inactivation and clearance is vital for comprehending its role in disease.