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The regulation of retinoic acid formation
1Department of Nutritional Sciences, University of California at Berkeley 94720-3104, USA.
Nutrition Reviews
|June 1, 1996
Abstract:
Rat liver microsomal as well as cytosolic retinol dehydrogenases from cellular retinal-binding protein (CRBP)-retinal from CRBP-retinol. A cytosolic dehydrogenase transforms retinal into retinoic acid. Apo-CRBP and ethanol inhibit the cytosolic but not the microsomal retinol dehydrogenase, the latter being the primary enzyme in the rate-limiting step in retinoic acid synthesis.