Protein-glycosaminoglycan interactions: infectiological aspects

Glycosaminoglycans (GAGs) are linear heteropolysaccharides consisting of repeated disaccharide units that are variably N- and O-sulfated. Due to this heterogeneity, GAGs possess a high amount of structural information. Linked to a protein core to form a proteoglycan, GAGs are present on the surface of probably all mammalian tissues. During the recent years, a number of pathogens ranging from viruses to protozoans were found to interact specifically with cell surface GAGs to recognize and bind to their target cells. This review is intended to give a short overview over protein-GAG interaction under the aspects of infection.