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Immersion diuresis in dogs

J T Davis, A B DuBois

    Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology
    |June 1, 1977
    PubMed
    Summary
    This summary is machine-generated.

    Immersion diuresis in dogs is likely initiated by hemodilution, not left atrial stretch. This early diuresis mechanism was investigated through various experimental conditions.

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    Area of Science:

    • Physiology
    • Renal Physiology
    • Cardiovascular Physiology

    Background:

    • Immersion in water can lead to significant fluid shifts and diuresis.
    • The precise physiological mechanisms driving immersion diuresis remain incompletely understood.
    • Previous hypotheses implicated atrial stretch and associated reflexes.

    Purpose of the Study:

    • To investigate the role of left atrial transmural pressure and hemodilution in early immersion diuresis in anesthetized dogs.
    • To determine if left atrial stretch is a causative factor in immersion-induced diuresis.
    • To explore the contribution of vagal reflexes to immersion diuresis.

    Main Methods:

    • Measurement of left atrial transmural pressure before, during, and after immersion.
    • Bilateral cervical vagotomy to assess the role of vagal reflexes.

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  • Negative-pressure breathing to simulate immersion-related thoracic pressure changes.
  • Blood studies including hemodilution measurements in splenectomized dogs.

    • Main Results:

    • Diuresis occurred independently of left atrial stretch, ruling out a direct causal relationship.
    • Immersion diuresis persisted in some dogs after vagotomy, suggesting non-vagal mechanisms.
    • Negative-pressure breathing induced diuresis and hemodilution without significant changes in atrial pressure.
    • Hemodilution was observed during immersion, particularly in dogs with kidneys removed, and sufficiently explained early diuresis.

    Conclusions:

    • Hemodilution is the probable initiator of early immersion diuresis in anesthetized dogs.
    • Left atrial stretch does not appear to be causally related to diuresis during immersion or negative-pressure breathing in dogs.
    • The findings challenge the role of atrial stretch reflexes in mediating immersion diuresis in this model.