Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Stimulus-sensitive seizures in postanoxic coma

A C Van Cott1, I Blatt, R P Brenner

  • 1Department of Neurology, University of Pittsburgh, School of Medicine, Pennsylvania 15213, USA.

Epilepsia
|September 1, 1996
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Seizures in E200K familial and sporadic Creutzfeldt-Jakob disease.

Acta neurologica Scandinavica·2014
Same author

Clinical and electroencephalographic findings in acutely ill adults with non-convulsive vs convulsive status epilepticus.

Acta neurologica Scandinavica·2014
Same author

Outcome of lamotrigine treatment in juvenile myoclonic epilepsy.

Acta neurologica Scandinavica·2011
Same author

Epilepsy syndrome-associated balance dysfunction assessed by static posturography.

Seizure·2010
Same author

Trends in antiepileptic drug prescribing for older patients with new-onset epilepsy: 2000-2004.

Neurology·2008
Same author

Non-stroke neurological syndromes associated with antiphospholipid antibodies: evaluation of clinical and experimental studies.

Lupus·2003
Same journal

Factors associated with rapid pediatric acute seizure emergency treatment: Quality Improvement in Time to Treat Status Epilepticus baseline cohort.

Epilepsia·2026
Same journal

Outcome trajectories after pediatric epilepsy surgery vary by biopsychosocial phenotypes.

Epilepsia·2026
Same journal

Comparative risk of epilepsy with SGLT2 inhibitors versus incretin-based therapies in type 2 diabetes.

Epilepsia·2026
Same journal

Long-term mortality after status epilepticus: A 5-year analysis study.

Epilepsia·2026
Same journal

The Epilepsy-Cog study: Methods to establish a harmonized study of late onset epilepsy in a metacohort of six population-based cohorts in the United States.

Epilepsia·2026
Same journal

Systematic review and meta-analysis of lifestyle modification interventions and their impact on seizure reduction and quality of life.

Epilepsia·2026
See all related articles

Severe hypoxic-ischemic injury can lead to stimulus-sensitive seizures and myoclonus. This condition, characterized by epileptiform discharges on EEG, is associated with a poor prognosis and resistance to antiepileptic drugs.

Area of Science:

  • Neurology
  • Neuroscience
  • Epileptology

Background:

  • Severe hypoxic-ischemic injury is a critical neurological event.
  • Myoclonus and seizures are potential sequelae of such injuries.
  • Stimulus-sensitive epilepsy presents unique diagnostic and management challenges.

Purpose of the Study:

  • To describe four adult patients presenting with stimulus-sensitive seizures and myoclonus following hypoxic-ischemic injury.
  • To characterize the clinical and electroencephalographic (EEG) findings in these patients.
  • To evaluate the association between these neurological manifestations and clinical outcomes.

Main Methods:

  • Retrospective review of EEG and hospital records for four adult patients over 22 months.
  • Identification of patients with myoclonus and generalized tonic-clonic/clonic seizures triggered by tactile stimulation.

Related Experiment Videos

  • Analysis of EEG patterns, including epileptiform discharges and cerebral activity between seizures.

    • Main Results:

    • Patients exhibited myoclonus and seizures triggered by tactile stimulation.
    • EEG revealed generalized spike and polyspike bursts correlating with seizures, with periods of suppression between bursts.
    • All patients were refractory to antiepileptic drug treatment and ultimately deceased.

    Conclusions:

    • Stimulus-sensitive seizures and myoclonus following anoxia are indicative of a severe neurological state.
    • The findings confirm that post-anoxic myoclonus, when accompanied by epileptiform discharges, represents an epileptic condition.
    • The study highlights the poor prognosis associated with this post-anoxic neurological sequela.