Differential roles for IL-12 in the maintenance of immune responses in infectious versus autoimmune disease
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Updated: Aug 17, 2026

Isolation and Th17 Differentiation of Naïve CD4 T Lymphocytes
Published on: September 26, 2013
R A Seder1, B L Kelsall, D Jankovic
1Laboratory of Clinical Investigation, National Institutes of Health, Bethesda, MD 20892, USA. rseder@nih.gov
Abstract:
IL-12 has been shown to be important in the generation of a functional Th1 response in animal models of both infectious and autoimmune disease. Furthermore, the role of IL-12 in the maintenance of the immune responses in these diseases is now emerging. Herein, we discuss the idea that memory responses for certain infections may be IL-12 independent, whereas memory responses for specific autoimmune diseases still require IL-12 to maintain a pathogenic response.
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