Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Elevated plasma adrenomedullin level in hyperthyroidism

M Taniyama1, K Kitamura, Y Ban

  • 1Third Department of Internal Medicine, Showa University, Tokyo, Japan.

European Journal of Clinical Investigation
|June 1, 1996
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Hyperthermo-chemo-radiotherapy as a definitive treatment for patients with early esophageal carcinoma.

American journal of clinical oncology·1992
Same author

A new chemotherapy against pseudomyxoma peritonei.

The American journal of gastroenterology·1992
Same author

Local administration of monoclonal antibody-drug conjugate: a new strategy to reduce the local recurrence of colorectal cancer.

Cancer research·1992
Same author

Endoscopic diagnosis of early carcinoma of the esophagus using Lugol's solution.

Gastrointestinal endoscopy·1992
Same author

Synergistic effects of intratumor administration of cis-diamminedichloroplatinum(II) combined with local hyperthermia in melanoma bearing mice.

Journal of surgical oncology·1992
Same author

Crystal structure of papain-E64-c complex. Binding diversity of E64-c to papain S2 and S3 subsites.

The Biochemical journal·1992
Same journal

Pacemaker Status and 5-Year Mortality After TAVI: A Sex-Specific Analysis.

European journal of clinical investigation·2026
Same journal

Causal Effects of Time-Varying Treatments: The G-Formula.

European journal of clinical investigation·2026
Same journal

Improving Scientific Research: Renegotiated Principles of Science, Proposals, Failures, and Successes.

European journal of clinical investigation·2026
Same journal

Beta-Blockers After Myocardial Infarction With Preserved and Mildly Reduced Ejection Fraction: A Meta-Analysis With Trial Sequential Analysis.

European journal of clinical investigation·2026
Same journal

Prognostic Role of Serum Albumin Levels in Elderly Patients With Non-Valvular Atrial Fibrillation.

European journal of clinical investigation·2026
Same journal

Circulating Human Epididymis Protein 4 Predicts 10-Year Mortality and Major Adverse Cardiovascular Events in Patients With Peripheral Artery Disease.

European journal of clinical investigation·2026
See all related articles

Elevated adrenomedullin levels were found in patients with Graves' disease, a form of hyperthyroidism. This peptide may explain the observed blood vessel dilation and lower blood pressure in thyrotoxicosis.

Area of Science:

  • Endocrinology
  • Cardiovascular Physiology

Background:

  • Adrenomedullin is a peptide with potent vasodilatory properties.
  • Thyrotoxicosis is associated with significant hemodynamic alterations, including decreased peripheral vascular resistance.

Purpose of the Study:

  • To investigate the role of adrenomedullin in the hemodynamic changes characteristic of thyrotoxicosis.
  • To measure plasma adrenomedullin concentrations in patients with Graves' disease.

Main Methods:

  • Plasma adrenomedullin levels were quantified in hyperthyroid patients and euthyroid controls.
  • Correlation analysis was performed between adrenomedullin levels and thyroid hormone concentrations.

Main Results:

  • Plasma adrenomedullin concentrations were significantly higher in hyperthyroid patients (14.7 ± 5.7 pmol/L) compared to controls (5.6 ± 1.3 pmol/L).

Related Experiment Videos

  • A trend towards a correlation was observed between plasma adrenomedullin and free thyroid hormones.
  • Lower mean blood pressure was noted in patients with elevated adrenomedullin.

    • Conclusions:

    • Elevated plasma adrenomedullin may contribute to the vasodilatation observed in thyrotoxicosis.
    • Adrenomedullin is implicated as a potential mediator of hemodynamic changes in hyperthyroidism.