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Related Experiment Videos

Measuring atopy in a multi-centre epidemiological study

S Chinn1, D Jarvis, C M Luczynska

  • 1Department of Public Health Medicine, Guy's and St. Thomas's Medical and Dental School, University of London, UK.

European Journal of Epidemiology
|April 1, 1996
PubMed
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Skin prick tests for atopy can vary by fieldworker. Using a > 0 mm cutoff for positive results improves comparability across different centers in epidemiological studies.

Area of Science:

  • Allergy and immunology
  • Epidemiology
  • Respiratory health

Background:

  • Skin prick tests (SPT) are crucial for assessing atopy in epidemiological research.
  • SPT results can be influenced by individual fieldworker techniques, impacting data comparability across study sites.
  • Standardized reporting methods are essential for multi-center epidemiological studies.

Purpose of the Study:

  • To evaluate methods for reporting skin prick test results in multi-center epidemiological studies.
  • To determine if allergen wheal size should be adjusted for histamine wheal size.
  • To identify the most comparable cutoff diameter for positive SPT results.

Main Methods:

  • Analysis of data from over 1000 subjects across three English centers in the European Community Respiratory Health Survey.

Related Experiment Videos

  • Assessment of the relationship between allergen wheal diameter and histamine wheal diameter.
  • Comparison of different cutoff diameters (> 0 mm, >= 3 mm, mean wheal diameter) for reporting positive SPT results.

    • Main Results:

    • No consistent relationship was found between allergen wheal diameter and histamine wheal diameter across fieldworkers or allergens.
    • A cutoff of > 0 mm for a positive SPT result demonstrated greater consistency with specific IgE values between fieldworkers compared to other cutoffs.
    • The chosen cutoff criterion significantly influenced the comparability of results across different fieldworkers.

    Conclusions:

    • A > 0 mm cutoff for positive skin prick tests offers improved comparability in epidemiological studies, reducing fieldworker influence.
    • The analytical approach used can be adapted for other epidemiological studies to determine optimal reporting criteria for SPT.
    • Standardizing SPT reporting criteria is vital for reliable multi-center allergy research.