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Updated: Aug 7, 2026
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Ovine Lumbar Intervertebral Disc Degeneration Model Utilizing a Lateral Retroperitoneal Drill Bit Injury
Published on: May 25, 2017
Familial predisposition for degenerative disc disease. A case-control study
E D Simmons1, M Guntupalli, J M Kowalski
1Department of Orthopaedic Surgery, Buffalo General Hospital, State University of New York at Buffalo, USA.
Spine
|July 1, 1996
Summary
Familial factors increase the risk for degenerative disc disease. Relatives of patients with degenerative disc disease were more likely to have a family history of spinal issues and surgery.
Area of Science:
- Orthopedics
- Genetics
- Epidemiology
Background:
- Degenerative disc disease (DDD) risk factors include smoking and occupational hazards.
- The potential role of familial predisposition in DDD development is not well understood.
Purpose of the Study:
- To investigate whether familial factors contribute to the risk of developing lumbar degenerative disc disease.
- To determine if relatives of patients undergoing surgery for DDD are at higher risk for lower back pain or sciatica.
Main Methods:
- A case-control study compared relatives of 65 patients with lumbar DDD surgery to 67 controls undergoing non-spine orthopedic procedures.
- Standardized questionnaires and interviews were administered by a single observer to all participants.
Main Results:
- A positive family history of DDD was reported by 44.6% of relatives in the study group versus 25.4% in the control group.
- Spinal surgery history was reported by 18.5% of relatives in the study group, compared to 4.5% in the control group.
Conclusions:
- The study suggests a familial predisposition to degenerative disc disease exists.
- Genetic factors may play a role in DDD development alongside environmental and occupational risks.
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