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Related Experiment Videos

Inheritance of randomness

B A Afzelius1

  • 1Department of Ultrastructure Research, Stockholm University, Sweden. bafz@zub,su.se

Medical Hypotheses
|July 1, 1996
PubMed
Summary
This summary is machine-generated.

Genetic inheritance may explain random developmental outcomes like situs inversus and left-handedness. A two-allele model suggests balanced polymorphism for traits like left-handedness and potentially homosexuality.

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Area of Science:

  • Developmental Biology
  • Genetics
  • Human Biology

Background:

  • The mouse mutant iv exhibits random determination in developmental processes, with 50% of homozygotes showing situs inversus.
  • Situs inversus in human immotile-cilia syndrome is also attributed to similar inheritance patterns.
  • Left-handedness, with its high prevalence, is hypothesized to involve a balanced polymorphism advantage.

Purpose of the Study:

  • To investigate the genetic inheritance patterns of developmental asymmetry.
  • To explore the potential genetic basis for left-handedness and homosexuality.
  • To propose a two-allele model for traits exhibiting random determination.

Main Methods:

  • Analysis of mouse mutant iv inheritance patterns.
  • Comparison of prevalence and inheritance data for situs inversus, left-handedness, and homosexuality.

Related Experiment Videos

  • Modeling a two-allele genetic system to explain observed frequencies.

    • Main Results:

    • A two-allele model accurately predicts the 50% situs inversus incidence in homozygotes.
    • The model aligns with observed prevalence (12.5%) and inheritance patterns of left-handedness.
    • Similar statistical values suggest a comparable genetic basis for homosexuality.

    Conclusions:

    • A two-allele system, involving one allele for asymmetry control and another without control, explains random developmental outcomes.
    • Balanced polymorphism likely contributes to the high prevalence of left-handedness.
    • The proposed genetic model offers a potential explanation for the inheritance of homosexuality.