Cellular polarization induced by chemokines: a mechanism for leukocyte recruitment?

Chemokines are known to induce leukocyte adhesion to the endothelium and emigration into tissues. Here, Miguel Angel del Pozo and colleagues discuss how these molecules also appear to regulate the redistribution of cell adhesion receptors. Recruitment of adhesion molecules towards a cellular uropod in response to chemokines may represent a novel cooperative mechanism in the recruitment of leukocytes to sites of inflammation.