Related Experiment Videos
A new foreign policy: MHC class I molecules monitor the outside world
1Division of Lymphocyte Biology, Dana Farber Cancer Institute, Boston, MA 02115, USA. Kenneth_Rock@dfci.harvard.edu
Immunology Today
|March 1, 1996
Abstract:
Although most cells exclusively use their major histocompatibility complex (MHC) class I molecules to present peptides from endogenous proteins, phagocytes also use them to present exogenous antigens. Here, Kenneth Rock describes how this novel antigen-presenting pathway may play an important role in immune surveillance for intracellular bacteria or parasites, as well as for viral infections and tumors affecting somatic tissues.