[Somatostatin receptor scintigraphy. Methodology, indications, results]

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E G Eising1, D Bier, E J Knust

  • 1Klinik und Poliklinik f Nuklearmedizin der Universität, Essen.

Der Radiologe
|January 1, 1996
PubMed

Insights

Somatostatin receptor scintigraphy is a valuable tool for diagnosing various tumors, especially carcinoids and gastro-enteropathic tumors. Newer analogues like Octreoscan offer improved clinical results compared to older iodinated versions.

Area of Science:

  • Nuclear medicine
  • Oncology
  • Radiopharmacology

Background:

  • Somatostatin-receptor scintigraphy has established clinical utility.
  • Experience is primarily with gastro-enteropathic (GEP) tumors and carcinoids.
  • Applications extend to lung, lymphoma, renal, breast, and thyroid cancers.

Purpose of the Study:

  • To review the current clinical applications of somatostatin receptor imaging.
  • To present institutional experience with specific tumor types.

Main Methods:

  • Utilized somatostatin analogues for tumor imaging.
  • Compared iodinated analogues (e.g., [123I-Tyr3]-octreotide) with [111In-DTPA-D-Phe1]octreotide (Octreoscan).

Main Results:

  • [111In-DTPA-D-Phe1]octreotide (Octreoscan) demonstrated superior clinical results compared to iodinated analogues.
  • Somatostatin imaging is applicable across a range of malignancies.

Conclusions:

  • Somatostatin receptor imaging, particularly with Octreoscan, is a key diagnostic modality.
  • Further experience with carcinoids, GEP tumors, and medullary thyroid carcinomas is detailed.

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