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Presentation of antigens derived from microorganisms residing in host-cell vacuoles
D M Ojcius1, G Gachelin, A Dautry-Varsat
1Unite de Biologie des Interactions Cellulaires, Paris, France. ojcius@pasteur.fr
Trends in Microbiology
|February 1, 1996
Abstract:
Antigens presented by major histocompatibility complex molecules have been classified into those presented by 'endogenous' and 'exogenous' pathways. Some microorganisms reside within host-cell vacuoles that appear to avoid both pathways. Novel presentation mechanisms are being unraveled for these microorganisms, and their antigens, rather than being just peptides, can also consist of lipids or DNA fragments.