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Recent developments in antifungal therapy

J L Lesher1

  • 1Department of Medicine, Medical College of Georgia School of Medicine, Augusta, USA.

Dermatologic Clinics
|January 1, 1996
PubMed
Summary
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Recent advances in treating superficial fungal infections include new oral and topical therapies. Key agents like fluconazole, itraconazole, and terbinafine are discussed for conditions such as tinea and onychomycosis.

Area of Science:

  • Dermatology
  • Mycology
  • Pharmacology

Background:

  • Superficial fungal infections remain a common clinical challenge.
  • Treatment options have evolved significantly in recent years.

Purpose of the Study:

  • To review recent advancements in the treatment of superficial fungal infections.
  • To focus on newer oral and topical therapeutic agents.
  • To discuss the application of these agents in specific dermatophyte infections.

Main Methods:

  • Review of recent scientific literature on antifungal agents.
  • Focus on novel drugs including fluconazole, itraconazole, and terbinafine.
  • Discussion of therapeutic strategies for common fungal conditions.

Main Results:

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  • Newer agents like fluconazole, itraconazole, and terbinafine offer improved efficacy.
  • Oral therapies are increasingly important for difficult-to-treat or widespread infections.
  • Topical treatments continue to be refined for localized superficial fungal infections.

Conclusions:

  • Fluconazole, itraconazole, and terbinafine represent significant progress in antifungal therapy.
  • The management of tinea corporis, tinea cruris, tinea pedis, tinea capitis, and onychomycosis has been enhanced by these agents.
  • Further research into optimal use and resistance patterns is warranted.