Related Experiment Videos
Typhoid hepatitis: report of two cases
V Sharma1, T S Thakur, S S Thakur
1Department of Microbiology, Indira Gandhi Medical College, Shimla.
Indian Journal of Medical Sciences
|July 1, 1995
Summary
Typhoid hepatitis, though rare, is a significant clinical presentation of enteric fever. Recognizing this hepatic involvement is crucial for accurate diagnosis, especially in endemic areas.
Area of Science:
- Hepatology
- Infectious Diseases
- Gastroenterology
Background:
- Enteric fever, commonly caused by Salmonella Typhi, often presents with systemic symptoms.
- Hepatic involvement in enteric fever is frequently observed through biochemical abnormalities (23-60% of cases).
- Early hepatic changes are typically linked to generalized bacteremia and pyrexial stage complications.
Observation:
- Clinical jaundice as an early sign of enteric fever is uncommon.
- Typhoid hepatitis has been historically overlooked as a distinct clinical entity.
- This report emphasizes the diagnostic importance of typhoid hepatitis.
Findings:
- Early hepatic changes in enteric fever are attributed to bacteremia and pyrexial stage lesions.
- Typhoid hepatitis, characterized by jaundice, warrants consideration in differential diagnosis.
- The study highlights the clinical significance of typhoid hepatitis.
Implications:
- Accurate diagnosis of enteric fever can be improved by considering typhoid hepatitis.
- This is particularly relevant in regions endemic for enteric fever and co-endemic for viral hepatitis and hepatic amoebiasis.
- Recognizing typhoid hepatitis aids in timely and appropriate patient management.