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Related Experiment Videos

Stratum corneum structure and function correlates with phenotype in psoriasis

R Ghadially1, J T Reed, P M Elias

  • 1Dermatology Service, Veterans Administration Medical Center, San Francisco, CA 94121, USA.

The Journal of Investigative Dermatology
|October 1, 1996
PubMed
Summary
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Psoriasis involves a defective skin barrier. This study shows barrier dysfunction, particularly in severe psoriasis phenotypes, correlating with impaired lamellar body secretion and extracellular bilayer formation, suggesting external triggers.

Area of Science:

  • Dermatology
  • Skin Biology
  • Epidermal Homeostasis

Background:

  • Psoriasis is characterized by epidermal dysfunction, including a compromised permeability barrier.
  • While immune dysregulation is often implicated, the role of epidermal barrier defects is increasingly recognized.
  • Barrier homeostasis relies on lamellar body secretion and extracellular processing into lipid bilayers.

Purpose of the Study:

  • To investigate the hypothesis that psoriasis is triggered by external factors.
  • To assess epidermal permeability barrier function, lamellar body structure, and extracellular lamellar bilayer formation in untreated psoriatic patients.
  • To correlate barrier defects with specific psoriatic phenotypes.

Main Methods:

  • Assessed transepidermal water loss (TEWL) to measure barrier function.

Related Experiment Videos

  • Examined epidermal lamellar body structure and secretion via electron microscopy.
  • Evaluated extracellular lamellar bilayer formation in psoriatic skin samples from different phenotypes.

    • Main Results:

    • Erythrodermic and active plaque psoriasis showed elevated TEWL, increased retained lamellar bodies, and sparse extracellular lamellae.
    • Chronic plaque psoriasis and sebopsoriasis exhibited less severe TEWL elevation, fewer retained lamellar bodies, and more extracellular material.
    • Barrier disruption severity correlated with defects in lamellar body secretion and extracellular bilayer formation.

    Conclusions:

    • Epidermal permeability barrier function is significantly disrupted in severe psoriatic phenotypes.
    • Abnormalities in lamellar body processing and secretion are key features of psoriatic barrier defects.
    • Findings support the hypothesis that altered barrier function may drive psoriasis onset (Koebner phenomenon) and phenotype variations.