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Related Experiment Videos

Genetic variation and aging

J W Curtsinger1, H H Fukui, A A Khazaeli

  • 1Department of Ecology, Evolution, and Behavior, University of Minnesota, St. Paul 55108, USA.

Annual Review of Genetics
|January 1, 1995
PubMed
Summary
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Genetic factors influence lifespan across diverse species, from yeast to humans. Research explores candidate genes and evolutionary theories, employing demographic techniques to understand aging.

Area of Science:

  • Gerontology
  • Genetics
  • Evolutionary Biology

Background:

  • Lifespan is genetically influenced in numerous organisms, including yeast, nematodes, fruit flies, and humans.
  • While single-gene mutants extend lifespan in some species, lifespan is often a quantitative trait with moderate heritability.
  • Artificial selection demonstrates lifespan's responsiveness in model organisms like Drosophila and Caenorhabditis.

Purpose of the Study:

  • To review the genetic basis of lifespan.
  • To discuss current research on candidate genes and evolutionary theories of aging.
  • To highlight the growing role of demographic analytical techniques in aging research.

Main Methods:

  • Review of existing literature on lifespan genetics and aging research.

Related Experiment Videos

  • Investigation of genetic mutants and artificial selection experiments.
  • Analysis of evolutionary models of senescence (antagonistic pleiotropy, mutation accumulation).

    • Main Results:

    • Lifespan is modifiable by genetics across a wide range of species.
    • Candidate genes, including antioxidant enzymes and heat-shock proteins, are under investigation.
    • Existing evolutionary models of senescence lack substantial experimental support.

    Conclusions:

    • Genetics plays a significant role in determining lifespan.
    • Further research is needed to experimentally validate evolutionary theories of aging.
    • Demographic approaches are increasingly important for advancing aging research.