Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Microsatellites: evolution and mutational processes

N B Freimer1, M Slatkin

  • 1Department of Psychiatry, University of California, San Francisco 94143-0984, USA.

Ciba Foundation Symposium
|January 1, 1996
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Obesity and obesogenic growth are both highly heritable and modified by diet in a nonhuman primate model, the African green monkey (Chlorocebus aethiops sabaeus).

International journal of obesity (2005)·2017
Same author

Cortical abnormalities in bipolar disorder: an MRI analysis of 6503 individuals from the ENIGMA Bipolar Disorder Working Group.

Molecular psychiatry·2017
Same author

A phenome-wide examination of neural and cognitive function.

Scientific data·2016
Same author

Subcortical volumetric abnormalities in bipolar disorder.

Molecular psychiatry·2016
Same author

Adult age confounds estimates of static allometric slopes in a vertebrate.

Ethology, ecology & evolution·2016
Same author

Genome-wide association study of Tourette's syndrome.

Molecular psychiatry·2012
Same journal

Precision agriculture: spatial and temporal variability of environmental quality. General reflections.

Ciba Foundation symposium·1997
Same journal

Uncertainty in hydrogeological modelling.

Ciba Foundation symposium·1997
Same journal

Optimal mapping of site-specific multivariate soil properties.

Ciba Foundation symposium·1997
Same journal

Modelling for precision weed management.

Ciba Foundation symposium·1997
Same journal

GIS support for precision agriculture: problems and possibilities.

Ciba Foundation symposium·1997
Same journal

Spatial sampling.

Ciba Foundation symposium·1997
See all related articles

Microsatellites, or simple sequence repeats, are key genetic markers. Their mutations are linked to inherited diseases and cancer, highlighting their importance in human genetics and population studies.

Area of Science:

  • Genomics
  • Molecular Biology
  • Population Genetics

Background:

  • Microsatellites (simple sequence repeats) are abundant and polymorphic DNA sequences in eukaryotic genomes.
  • They are crucial for genetic mapping and studying population differentiation in mammals.
  • Microsatellite mutations are increasingly implicated in inherited human diseases and serve as cancer markers.

Purpose of the Study:

  • To review the role and mutational mechanisms of microsatellites in eukaryotic genomes.
  • To explore the implications of microsatellite variation in human diseases and population genetics.
  • To investigate the structural complexity and constraints on microsatellite evolution.

Main Methods:

  • Review of existing literature on microsatellite genetics, mutation, and disease association.

Related Experiment Videos

  • Comparative analysis of microsatellite allele frequencies across species (e.g., humans and chimpanzees).
  • Sequence analysis of microsatellites to understand structural variations beyond repeat length.

    • Main Results:

    • Microsatellite mutations, primarily via replication slippage, contribute to allele distributions and are linked to diseases like inherited disorders and cancers.
    • Comparative studies reveal length constraints on microsatellites between humans and chimpanzees.
    • Sequence analysis indicates microsatellite alleles vary in base composition, not just length, with single base changes potentially increasing mutation rates.

    Conclusions:

    • Microsatellites are vital genetic tools with complex structures and mutation dynamics.
    • Understanding microsatellite instability, particularly trinucleotide repeat expansions, is critical for diagnosing and potentially treating associated inherited diseases.
    • Microsatellite research continues to advance genetic mapping, population studies, and disease marker development.